Nico appeared in the alternate-reality five-issue What If? series at the end of 2008. She used the staff five times during the series.

Her first use was against the Wrecking Crew when she froze Piledriver in his tracks with 'Stone Cold' [What If: House of M #1]

Nico attempts to stop Chase's internal bleeding by using 'Clot' to stop the blood flow [What If: Newer Fantastic Four #1]

She then removes Victor Mancha's stolen Iron Lad armor with a simple spell. 'canopener' [What If: Newer Fantastic Four #1]

When in battle with both Victor Mancha and Victorious, Nico uses 'Rubber Soul' to bounce their energy attacks back to themselves [What If: Secret Wars #1]

Nico then uses her staff in a more offensive manner, crushing Victorious between two magical hands with 'Applause.' The color of the hands resembles the Prodigum Effedio spell's demon from the first Young Avengers/Runaways mini-series [What If: Secret Wars #1]